Throughout the year, we ask questions of the most plugged-in San Francisco 49ers fans and fans across the country. Sign up ...

This has led to a profound resource drain to the 49ers. They kept up their turn-and-burn roster approach of letting guys ...

Will the Bears be able to break their losing streak and get a big road win? San Francisco 49ers SB Nation site: Niners Nation ...

The 49ers backfield is further and further depleted. Running back Isaac Guerendo is the latest to suffer an injury. We break ...

Christan McCaffrey appeared to come up limp and had to slide down without contact in the second quarter against the Bills. We ...

Kyle Shanahan can no longer save the San Francisco 49ers. We have reached the month of December and quite the time in the NFL ...

San Francisco 49ers offensive tackle Trent Williams and his wife, Sondra Williams, have issued a heartbreaking statement at ...

SANTA CLARA, Calif. (AP) — San Francisco 49ers star running back Christian McCaffrey will not need surgery on his injured right knee but he will miss the rest of the regular season. Coach Kyle ...