San Francisco 49ers tight end George Kittle is one of six players nominated for the FedEx Air & Ground Player of Week 14 ...

The San Francisco 49ers may be down to their fourth-string running back Thursday against the Los Angeles Rams. Head coach ...

The San Francisco 49ers throttled the Chicago Bears on Sunday, 38-13. After back-to-back forgettable defensive performances ...

After losing by a margin of 73-20 in their last two games, and carrying a three-game losing streak, the Niners turned in ...

The San Francisco 49ers can't seem to catch a break.Injuries have plagued San Francisco all season, and the Niners will have ...

The San Francisco 49ers are making a major contract decision that could lead to the release of a two-time Pro Bowler.

With Christian McCaffrey and Jordan Mason on injured reserve, Guerendo made his first NFL start against the Bears. If he ...

After getting back to winning ways, San Francisco 49ers head coach Kyle Shanahan gave a clear verdict on recent trade rumors.

Here's the latest injury news on Derek Carr, Drew Lock and Isaac Guerendo and entering Week 15 of the NFL season.

The Chicago Bears (4-8) released their second injury report ahead of Sunday's Week 14 game against the San Francisco 49ers (5 ...

NFL.com's Eric Edholm breaks down four things to watch for when the Los Angeles Rams kick off Week 15 at the division rival San Francisco 49ers on Thursday night.

The San Francisco 49ers take on the Los Angeles Rams at 5:15 p.m. PDT on Thursday, Dec. 12 at Levi’s Stadium in San Francisco ...